Journal of Bioscience and Agriculture Research |
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RESEARCH ARTICLE:
Analgesic effects of ethanolic leaf extract of Ludwigia adscendens (L.) H. Hara over selective drugs in in vivo
A. N. M. Shofi Uddin (1), Gazi Md. Monjur Murshid (1), Salauddin Al Azad (2) and Md. Faysal Al Mazid (2)
1 Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh
2 Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh
Article information:
Received date: 16.04.18, Revised date: 18.07.18, First available online date: 15 September, 2018.
J. Bios. Agric. Res. | Volume 17, Issue 02, Page number: 1436-1441
Crossref DOI: https://doi.org/10.18801/jbar.170218.178
Analgesic effects of ethanolic leaf extract of Ludwigia adscendens (L.) H. Hara over selective drugs in in vivo
A. N. M. Shofi Uddin (1), Gazi Md. Monjur Murshid (1), Salauddin Al Azad (2) and Md. Faysal Al Mazid (2)
1 Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh
2 Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh
Article information:
Received date: 16.04.18, Revised date: 18.07.18, First available online date: 15 September, 2018.
J. Bios. Agric. Res. | Volume 17, Issue 02, Page number: 1436-1441
Crossref DOI: https://doi.org/10.18801/jbar.170218.178
FULL TEXT PDF:
| 178.02.17.18_analgesic_effects_of_ethanolic_leaf_extract_of_ludwigia_adscendens__l.__h._hara_over_selective_drugs_in_in_vivo.pdf |
Analgesic effects of ethanolic leaf extract of Ludwigia adscendens (L.) H. Hara over selective drugs in in vivo
Abstract
Ludwigia adscendens (L.) H. Hara is commonly referred as weed which mainly grow in paddy field in the Asia, Australia and Africa. A number of antioxidants present in this species and have a large therapeutic background. To evaluate the analgesic activity of the ethanolic extract of Ludwigia adscendens (L.) H.Hara leaf on Swiss-albino mice (as experimental model) through Acetic Acid Induced Writhing Method. Acute toxicity experiment of the ethanolic extract of Ludwigia adscendens (L.) H.Hara leaf were performed whereby dose of 250 mg/ kg and 500 mg/kg was selected in this present study. Analgesic activity was observed using acetic acid induced writhing pain in mice. Ludwigia adscendens (L.) H. Hara showed Significant (P<0.05) in Extract (250 mg/kg) and (P<0.001) in Extract (500 mg/kg) in this experimental model. These studies conclude that Ludwigia adscendens (L.) H.Hara possesses positive analgesic properties which might be due to presence of antioxidants like flavonoids, phenolics and polysaccharides. The results provide a scientific basis for the centuries-old usages of aqueous extracts of this medicinal plant. HPLC and NMR might help us to specify different biochemical components, responsible for the therapeutic properties precisely.
Key Words: Analgesic activity, Ethanolic leaf extract, Diclofenac Na, Phyto-therapeutics and Ludwigia adscendens (L.) H.Hara
Abstract
Ludwigia adscendens (L.) H. Hara is commonly referred as weed which mainly grow in paddy field in the Asia, Australia and Africa. A number of antioxidants present in this species and have a large therapeutic background. To evaluate the analgesic activity of the ethanolic extract of Ludwigia adscendens (L.) H.Hara leaf on Swiss-albino mice (as experimental model) through Acetic Acid Induced Writhing Method. Acute toxicity experiment of the ethanolic extract of Ludwigia adscendens (L.) H.Hara leaf were performed whereby dose of 250 mg/ kg and 500 mg/kg was selected in this present study. Analgesic activity was observed using acetic acid induced writhing pain in mice. Ludwigia adscendens (L.) H. Hara showed Significant (P<0.05) in Extract (250 mg/kg) and (P<0.001) in Extract (500 mg/kg) in this experimental model. These studies conclude that Ludwigia adscendens (L.) H.Hara possesses positive analgesic properties which might be due to presence of antioxidants like flavonoids, phenolics and polysaccharides. The results provide a scientific basis for the centuries-old usages of aqueous extracts of this medicinal plant. HPLC and NMR might help us to specify different biochemical components, responsible for the therapeutic properties precisely.
Key Words: Analgesic activity, Ethanolic leaf extract, Diclofenac Na, Phyto-therapeutics and Ludwigia adscendens (L.) H.Hara
HOW TO CITE THIS ARTICLE?
APA (American Psychological Association)
Uddin, A. N. M. S., Murshid, G. M. M., Azad, S. A. & Mazid, M. F. A. (2018). Analgesic effects of ethanolic leaf extract of Ludwigia adscendens (L.) H. Hara over selective drugs in in vivo. Journal of Bioscience and Agriculture Research, 17(02), 1436-1441.
MLA (Modern Language Association)
Uddin, A. N. M. S., Murshid, G. M. M., Azad, S. A. and Mazid, M. F. A. “Analgesic effects of ethanolic leaf extract of Ludwigia adscendens (L.) H. Hara over selective drugs in in vivo”. Journal of Bioscience and Agriculture Research, 17.02(2018): 1436-1441.
Chicago and or Turabian
Uddin, A. N. M. S., Murshid, G. M. M., Azad, S. A. and Mazid, M. F. A. “Analgesic effects of ethanolic leaf extract of Ludwigia adscendens (L.) H. Hara over selective drugs in in vivo”. Journal of Bioscience and Agriculture Research, 17 no.02(2018): 1436-1441.
APA (American Psychological Association)
Uddin, A. N. M. S., Murshid, G. M. M., Azad, S. A. & Mazid, M. F. A. (2018). Analgesic effects of ethanolic leaf extract of Ludwigia adscendens (L.) H. Hara over selective drugs in in vivo. Journal of Bioscience and Agriculture Research, 17(02), 1436-1441.
MLA (Modern Language Association)
Uddin, A. N. M. S., Murshid, G. M. M., Azad, S. A. and Mazid, M. F. A. “Analgesic effects of ethanolic leaf extract of Ludwigia adscendens (L.) H. Hara over selective drugs in in vivo”. Journal of Bioscience and Agriculture Research, 17.02(2018): 1436-1441.
Chicago and or Turabian
Uddin, A. N. M. S., Murshid, G. M. M., Azad, S. A. and Mazid, M. F. A. “Analgesic effects of ethanolic leaf extract of Ludwigia adscendens (L.) H. Hara over selective drugs in in vivo”. Journal of Bioscience and Agriculture Research, 17 no.02(2018): 1436-1441.
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