Journal of Molecular Studies and Medicine Research |
|
Research Article:
Opsonin and its mechanism of action in secondary immune response
Salauddin Al Azad (1), Sayeed Shahriyar (2) and Kanak Jyoti Mondal (3)
1Biotechnology and Genetic Engineering Discipline,Khulna University, Bangladesh
2Dept. of Biotechnology, Bangladesh Agricultural University, Mymenshingh, Bangladesh
3Dept. of Medicine, Khulna Medical College, Khulna, Bangladesh
J. Mole. Stud. Medici. Res., Volume 01, Issue 02, pp. 48-56 | Available online: 25 March 2016
DOI: 10.18801/jmsmr.010216.06
Opsonin and its mechanism of action in secondary immune response
Salauddin Al Azad (1), Sayeed Shahriyar (2) and Kanak Jyoti Mondal (3)
1Biotechnology and Genetic Engineering Discipline,Khulna University, Bangladesh
2Dept. of Biotechnology, Bangladesh Agricultural University, Mymenshingh, Bangladesh
3Dept. of Medicine, Khulna Medical College, Khulna, Bangladesh
J. Mole. Stud. Medici. Res., Volume 01, Issue 02, pp. 48-56 | Available online: 25 March 2016
DOI: 10.18801/jmsmr.010216.06
Full Text PDF:

opsonin_and_its_mechanism_of__action_in_secondary_immune_response.pdf |
Title: Opsonin and its mechanism of action in secondary immune response
Abstract: Opsonins are specialized biomolecules responsible for recognizing the pathogens to be crushed by our immunity which, is considered as the main precursor of undergoing any phagocytosis reaction inside the body environment. In the absence of these molecules autoimmunity and hypersensitivity may take place on regular basis. A number of research programs and projects have been launching for the opsonin research purpose, where new theories of human immunity and molecular interference in our defense mechanism are revealed from each project. Complement cascade produces opsonin as a by-product. The complement receptor 3(CR3) and Fc gammareceptor (FcgamaRs), two important phagocytic receptors, mediate phagocytosis in the cellular level. In the following passages the pathways of opsonin activity in secondary immune response, mechanism of phagocytosis reaction, role of other complement system and antibody in defense purposes, clinical aspects of opsonization and the future of opsonin research are described quite transparently. The molecular structures and proteomic modeling is the main way of revealing new technologies of drug designing both in molecular and nano-scale level.
Key Words: Phagocytosis, Complement, Immune system, Receptor and Defense mechanisms
Abstract: Opsonins are specialized biomolecules responsible for recognizing the pathogens to be crushed by our immunity which, is considered as the main precursor of undergoing any phagocytosis reaction inside the body environment. In the absence of these molecules autoimmunity and hypersensitivity may take place on regular basis. A number of research programs and projects have been launching for the opsonin research purpose, where new theories of human immunity and molecular interference in our defense mechanism are revealed from each project. Complement cascade produces opsonin as a by-product. The complement receptor 3(CR3) and Fc gammareceptor (FcgamaRs), two important phagocytic receptors, mediate phagocytosis in the cellular level. In the following passages the pathways of opsonin activity in secondary immune response, mechanism of phagocytosis reaction, role of other complement system and antibody in defense purposes, clinical aspects of opsonization and the future of opsonin research are described quite transparently. The molecular structures and proteomic modeling is the main way of revealing new technologies of drug designing both in molecular and nano-scale level.
Key Words: Phagocytosis, Complement, Immune system, Receptor and Defense mechanisms
APA (American Psychological Association)
Azad, S. A., Shahriyar, S. & Mondal, K. J. (2016). Opsonin and its mechanism of action in secondary immune response. Journal of Molecular Studies and Medicine Research, 01(02), 48-56.
MLA (Modern Language Association)
Azad, S. A., Shahriyar, S. & Mondal, K. J. ''Opsonin and its mechanism of action in secondary immune response.'' Journal of Molecular Studies and Medicine Research, 01.02. (2016): 48-56.
Chicago/Turabian
Azad, S. A., Shahriyar, S. & Mondal, K. J. Opsonin and its mechanism of action in secondary immune response. Journal of Molecular Studies and Medicine Research, 01, no. 02 (2016): 48-56.
Azad, S. A., Shahriyar, S. & Mondal, K. J. (2016). Opsonin and its mechanism of action in secondary immune response. Journal of Molecular Studies and Medicine Research, 01(02), 48-56.
MLA (Modern Language Association)
Azad, S. A., Shahriyar, S. & Mondal, K. J. ''Opsonin and its mechanism of action in secondary immune response.'' Journal of Molecular Studies and Medicine Research, 01.02. (2016): 48-56.
Chicago/Turabian
Azad, S. A., Shahriyar, S. & Mondal, K. J. Opsonin and its mechanism of action in secondary immune response. Journal of Molecular Studies and Medicine Research, 01, no. 02 (2016): 48-56.
- Barret, J. T. (1980). Basic immunology and its medical application (2nd Eds.), St. Louis: The C.V. Mosby Company.
- Caron, E. & Hall, A. (1998). Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Science, 282, 1717-1721.
- David, A., Lee, J. R., Hoidal, D. J., Garlich, C., Clawson, C., Quie, P. G. & Peterson, P. K. (1984). Opsonin independent phagocytosis of surface adherent bacteria by human alveolar macrophages. J. Leukoc. Biol., 36, 689-701.
- David, C. D., Boxer, V. & Liles, W. C. (2008). The Phagocytosis: neutrophils and monocytes; ASH 50th Anniversary Review; Blood, 112, 935-945.
- Didar, T. F., Watters, A., Leslie, D. C., Kang, J. H., Cartwright, M., Graveline, A., Waterhouse, A., Super, M. & Ingber, D. E. (2014). Opsonin coated hollow fibres for pathogen removal from following blood, 18th International Conference on Minimized Systems for Chemistry and Life Science, San Antonio, Texas, USA.
- Drevets, D. A. & Campbell, P. A. (1991). Roles of complement and complement receptor type 3 in phagocytosis of Listeria monocytogens by inflammatory mouse peritoneal macrophages. Infection and Immunity, pp. 2645-2651.
- Eddie, W. K., Takahashi, K., Ezekowitz, A. & Stuart, L. M. (2009). Mannose-binding lectin and innate immunity. Immunological Reviews, 230, 9-21.
- Janeway, C. A. Jr. (1989). Approaching the asymptote? Evoltion and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol., 54, 1-13.
- Karunasagar, I., Senghaas, B., Krohne, G. & Goebel, W. (1994). Ultra-structural study of Listeria monocytogens entry into cultured human colonic epithelial cells. Infect Immun., 62, 3554-3558.
- Kim, M. K., Huang, Z. Y. & Hwang, P. H. (2003). Fc gamma repector transmembrane domains: role in cell surface expression, gamma chain interaction and phagocytosis. Blood., 101, 4479-4484.
- Klebanoff, S. J. (1968). Myeloperoxidase-halide-hydrogen peroxide antibacterial system. J. Bacteriol., 95, 2131-2138.
- Matsui, H., Ito, T. & Ohnishi, S. I. (1983). Phagocytosis by Macrophages; III. Effects of Heat-Labile Opsonin and Poly (L-Lysin). J Cell Sci., 59, 133-143.
- May, R. C. & Machesky, L. M. (2001). Phagocytosis and the actin cytoskeleton. J. Cell Sci., 114, 1061-1077.
- Naccache, P. H., Volpi, M., Showell, H. J., Becker, E. L. & Shaafi, R. I. (1979). Chemotactic factor-induced release of membrane calcium in rabbit neutrophils. Science, 203, 461-463.
- Nasr, A. B., Haithcoat, J., Masterson, J. E., Gunn, J. S., Eaves-Pyles, T. & Klimpel, G. R. (2006). Cricital role for serum opsonins and complement receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18) in phagocytosis of Francisella leads to activation of immature DC and intracellular survival of the bacteria. J. Leukoc. Biol., 80, 774-786.
- Parent, C. A. (2004). Making all the right moves: chemotaxis in neutrophils and Dictyostelium. Curr. Opin. Cell Biol., 16, 4-13.
- Pierce, M. M., Gibson, R. E. & Rodgers, F. G. (1996). Opsonin independent adherence and phagocytosis of Listeria monocytogens by murine peritoneal macrophages. J. Med. Microbiol., 45, 258-262.
- Roitt, I. M., Delves, P. J., Martin, S. J. & Burton, D. R. (11th Eds.). (2006). Essential Immunology, pp. 1-3.
- Roitt, I. M., Delves, P. J., Martin, S. J. & Burton, D. R. (11th Eds.). (2006a). Essential Immunology, pp. 10-12.
- Roitt, I. M., Delves, P. J., Martin, S. J. & Burton, D. R. (11th Eds.). (2006b). Essential Immunology, pp. 462.
- Sbarra, A. J. & Karnovsky, M. L. (1959). The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by poly morpho nuclear leukocytes. J. Biol Chem., 234, 1355-1357.
- Schatz, D. G., Oettinger, M. A. & Schlissel, M. S. V. (1992). J. recombination: molecular biology and regulation. Annu. Rev. Immunol., 10, 359-383.
- Shapiro, S., Kohn, D. & Gershon, H. (1993). A role for complement as the major opsonin in the sequestration of erythrocytes from elderly and young donors. Br. J. Haematol., 83, 648-654.
- Smolen, J. E, Korchak, H. M. & Weissmann, G. (1980). Increased level of cyclic adenosine-3, 5 monophophate in human polymorphonuclear leukocytes after surface stimulation. J Clin Invest., 65, 1077-1085.
- Stossel, T. P. (1993). On the crawling of animal cells. Science., 260, 1086-1094.
- Sullivan, K. E. & Winkelstein, J. A. (2007). Genetically determined deficiencies of the complement system. In Ochs, H. D, Smith, C. I. E. & Puck, J. M, (Eds.), Primary Immune Deficiency Disease A Molecular and Genetic Approach. New York, NY: Oxford University Press. pp. 589-608.
- Valentine, W. N & Beck, W. S. (1951). Biochemical studies on leukocytes. I. Phosphatase activity in health leukocytosis, myelocytic leukemia. J. Lab. Clin. Med., 38, 39-42.
- Whitin, J. C, Chapman, C. E, Simons, E. R, Chovaniec, M. E. & Cohen, H. J. (1980). Correlation between membrane potential changes and superoxide production in human granulocytes stimulated by phorbol myristate: evidence for defective activation in chronic granulomatous disease. J. Bio.l Chem., 255, 1874-1878.
Open Access | Powered by Scribd
© Azad et al. (2016). This article published by Journal BiNET is freely available for anyone to read, share, download, print, permitted for unrestricted use and build upon, provided that the original author(s) and publisher are given due credit. All Published articles are distributed under the Creative Commons Attribution 4.0 International License.